Protein Details: Two pore potassium channel b

Protein ID

ICDB_Pro_1275

Protein Name

Two pore potassium channel b

Gene Name

TPKB; KCO2; Os07g0108800; LOC_Os07g01810; OJ1567_G09.108; OsJ_22819; P0585H11.123

Organism

Oryza sativa subsp. japonica (Rice)

Length

349 amino acids

AlphaFoldDB

AF-Q8LIN5-F1-model_v4.pdb

Function

Highly selective inward-rectifying potassium channel that is specifically located in the tonoplast of protein storage vacuoles. Functions independently of the voltage difference across the membrane.

Sequence

MAALDQQPLLHDGGDQKPPPEGAARRFRRCRTAPSSEPPPTDKDNSSAADAPPKTLFTGGGRPSFRLVGLLLVAYLLLGTIAFYLAMDHMSGTRTTRALDALYFCVVTMTTVGYGDLVPASDAAKLLACAFVFAGVAVVGTFLSKAADYLVEKQEALLFRALHSHTMVRAMEMNKVRYKLYTAGLLLVAAVASGTVVLWKVEGMRAVDAFYCVCATVTTLGYGDRSFSSEGGRAFAVAWITVSTVVVALFFLYAAELYTERRQRELARWVLRRRTTNMDLEAADLDGDHRVGAADFVLYKLKELGKISQEDISEFLDEFDNLDADHSGTLSPADLAAAQPTPDPPPSLR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

284;286;288;290;295;323;325;327;329;334

Disease

Location

DOI ID

10.1038/nature03895; 10.1093/nar/gkm978; 10.1186/1939-8433-6-4; 10.1371/journal.pbio.0030038; 10.1126/science.1081288; 10.1105/tpc.110.081463